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Gastroesophageal disorders

This section concerns all clinical and basic science aspects of gastroesophageal disorders including but not limited to: prevention, diagnosis and management, as well as related molecular genetics and pathophysiology.

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  1. The treatment for the eradication of Helicobacter pylori (H. pylori) is complex; full effectiveness is rarely achieved and it has many adverse effects. In developing countries, increased resistance to antibiotics...

    Authors: Tomás Navarro-Rodriguez, Fernando Marcuz Silva, Ricardo Correa Barbuti, Rejane Mattar, Joaquim Prado Moraes-Filho, Maricê Nogueira de Oliveira, Cristina S Bogsan, Décio Chinzon and Jaime Natan Eisig

    Citation: BMC Gastroenterology 2013 13:56

    Content type: Research article

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  2. Non-steroidal anti-inflammatory drugs (NSAIDs) are an effective and common treatment for chronic pain disorders, but long-term use is associated with risk of potentially life-threatening gastrointestinal adver...

    Authors: Kentaro Sugano, Yoshikazu Kinoshita, Hiroto Miwa and Tsutomu Takeuchi

    Citation: BMC Gastroenterology 2013 13:54

    Content type: Research article

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  3. Surface electrogastrography (EGG) is a non-invasive method for clinical assessment of gastric myoelectrical activity. Different forms of general anaesthesia might have various effects on porcine EGG. The aim o...

    Authors: Ilja Tachecí, Jaroslav Květina, Martin Kuneš, Michal Pavlík, Marcela Kopáčová, Vladimír Černý, Stanislav Rejchrt, Jithinraj Edakkanambeth Varayil and Jan Bureš

    Citation: BMC Gastroenterology 2013 13:48

    Content type: Research article

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  4. Gastrointestinal reflux disease (GERD) is a common disorder that negatively impacts health-related quality of life (HRQL) and work productivity. Many patients have only a partial response to proton pump inhibi...

    Authors: Stanislas Bruley des Varannes, Helena Granstedt Löfman, Maria Karlsson, Peter Wahlqvist, Magnus Ruth, Mary Lou Furstnau, Nicolas Despiégel and Nils-Olov Stålhammar

    Citation: BMC Gastroenterology 2013 13:39

    Content type: Research article

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  7. The transcription factor nuclear factor-κB (NF-κB) has been implicated in gastric cancer metastasis, but the underlying molecular mechanisms remain unclear. We investigated the role of the interaction between ...

    Authors: Jiyeon Yoon, Sung Jin Cho, Young San Ko, Jinju Park, Dong Hoon Shin, In Chan Hwang, Sang Yeun Han, Seon Young Nam, Min A Kim, Mee Soo Chang, Hye Seung Lee, Woo Ho Kim and Byung Lan Lee

    Citation: BMC Gastroenterology 2013 13:29

    Content type: Research article

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  8. Per oral endoscopic myotomy (POEM) has been reported to be a new therapeutic option for esophageal achalasia. The possibility that POEM could reduce the risk of developing esophageal squamous cell carcinoma wa...

    Authors: Hitomi Minami, Naoyuki Yamaguchi, Kayoko Matsushima, Yuko Akazawa, Ken Ohnita, Fuminao Takeshima, Toshiyuki Nakayama, Tomayoshi Hayashi, Haruhiro Inoue, Kazuhiko Nakao and Hajime Isomoto

    Citation: BMC Gastroenterology 2013 13:22

    Content type: Research article

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  9. Inadequate response to proton pump inhibitor (PPI) therapy in patients with gastroesophageal reflux disease (GERD) is reported in up to 40%. Patients with non erosive reflux disease (NERD) have lower response ...

    Authors: Arne Kandulski, Ulrich Peitz, Klaus Mönkemüller, Helmut Neumann, Jochen Weigt and Peter Malfertheiner

    Citation: BMC Gastroenterology 2013 13:12

    Content type: Research article

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  11. Ulceration of the oesophageal squamous mucosa (ulcerative oesophagitis) is a pathological manifestation of gastro-oesophageal reflux disease, and is a major risk factor for the development of Barrett’s oesopha...

    Authors: Cameron M Smith, Michael Z Michael, David I Watson, Grace Tan, David St J Astill, Richard Hummel and Damian J Hussey

    Citation: BMC Gastroenterology 2013 13:4

    Content type: Research article

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  12. Aberrant methylation patterns in CpG island are known to be influential in gene silencing. Histamine plays important physiological roles in the upper gastrointestinal tract and acts via the H2 receptor. We rep...

    Authors: Tomoe Nomura, Tomomitsu Tahara, Hisakazu Shiroeda, Takahiro Minato, Yasuhiro Matsue, Ranji Hayashi, Kazuhiro Matsunaga, Toshimi Otsuka, Masakatsu Nakamura, Nobuyuki Toshikuni, Tomoyuki Shibata and Tomiyasu Arisawa

    Citation: BMC Gastroenterology 2013 13:1

    Content type: Research article

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  13. The best sites for biopsy-based tests to evaluate H. pylori infection in gastritis with atrophy are not well known. This study aimed to evaluate the site and sensitivity of biopsy-based tests in terms of degree o...

    Authors: Hung-Chieh Lan, Tseng-Shing Chen, Anna Fen-Yau Li, Full-Young Chang and Han-Chieh Lin

    Citation: BMC Gastroenterology 2012 12:182

    Content type: Research article

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  14. Recent advances in the management of Barrett’s Esophagus (BE) have placed greater emphasis on accurate diagnosis of BE as well as better prediction of risk for progression to esophageal adenocarcinoma (EAC). H...

    Authors: Eric Ellsworth, Sara A Jackson, Shyam J Thakkar, Dennis M Smith Jr and Sydney Finkelstein

    Citation: BMC Gastroenterology 2012 12:181

    Content type: Research article

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  16. Pre-marketing clinical studies of tegaserod suggested an increased risk of abdominal surgery, particularly cholecystectomy. We sought to quantify the association between tegaserod use and the occurrence of abd...

    Authors: John D Seeger, Sherry Quinn, David L Earnest, Anthony Lembo, Braden Kuo, Elena Rivero and Alexander M Walker

    Citation: BMC Gastroenterology 2012 12:171

    Content type: Research article

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  17. Gastric intestinal metaplasia (IM) usually appears in flat mucosa and shows few morphologic changes, making diagnosis using conventional endoscopy unreliable. Magnifying narrow-band imaging (NBI) endoscopy ena...

    Authors: Jin Kwang An, Geun Am Song, Gwang Ha Kim, Do Youn Park, Na Ri Shin, Bong Eun Lee, Hyun Young Woo, Dong Yup Ryu, Dong Uk Kim and Jeong Heo

    Citation: BMC Gastroenterology 2012 12:169

    Content type: Research article

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  18. Rumination syndrome (RS) is a functional gastrointestinal disorder (FGD) increasingly recognized in children and adolescents. The epidemiology of this condition in school aged children is poorly understood. Th...

    Authors: Shaman Rajindrajith, Niranga Manjuri Devanarayana and Bonaventure Jayasiri Crispus Perera

    Citation: BMC Gastroenterology 2012 12:163

    Content type: Research article

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  19. Data about prevalence of gastroesophageal reflux diseases (GERD) from Asian populations are still scarce. To provide additional data on prevalence of GERD and investigate its potential risk factors, we perform...

    Authors: Tiantian Chen, Ming Lu, Xiaofeng Wang, Yajun Yang, Juan Zhang, Li Jin and Weimin Ye

    Citation: BMC Gastroenterology 2012 12:161

    Content type: Research article

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  20. High expression of Bmi-1, a key regulatory component of the polycomb repressive complex-1, has been associated with many solid and hematologic malignancies including esophageal squamous cell carcinoma. However...

    Authors: Bonnie Choy, Santhoshi Bandla, Yinglin Xia, Dongfeng Tan, Arjun Pennathur, James D Luketich, Tony E Godfrey, Jeffrey H Peters, Jun Sun and Zhongren Zhou

    Citation: BMC Gastroenterology 2012 12:146

    Content type: Research article

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  21. Gastric cancer is one of the most significant diseases, and esophago-gastro-duodenoscopy (EGD) is one of screening methods for gastric cancer. This study was conducted to identify the optimal screening interva...

    Authors: Daiki Kobayashi, Osamu Takahashi, Hiroko Arioka and Tsuguya Fukui

    Citation: BMC Gastroenterology 2012 12:144

    Content type: Research article

    Published on:

  22. Proton pump is an integral membrane protein that is ubiquitous ATP binding cassette (ABC) involved in many transport processes in all living organisms, among which a specialized form of pump, so called p-type pro...

    Authors: Ho-Jae Lee, Young-Min Han, Eun-Hee Kim, Yoon-Jae Kim and Ki-Baik Hahm

    Citation: BMC Gastroenterology 2012 12:143

    Content type: Research article

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  23. Asthmatics are known to have esophageal hypomotility. Vagal hypofunction and prolonged intra-esophageal acidification cause esophageal hypomotility. The contribution of gastroesophageal reflux (GER) and vagal ...

    Authors: D Lakmali Amarasiri, Arunasalam Pathmeswaran, Anuradha S Dassanayake, Arjuna P de Silva, Channa D Ranasinha and H Janaka de Silva

    Citation: BMC Gastroenterology 2012 12:140

    Content type: Research article

    Published on:

  24. Despite genetic polymorphism in response to platinum/5-Fu chemotherapy in gastric cancer (GC) has been studied, data reported so far are conflicting and critical consideration is needed before translation to t...

    Authors: Zhen Wang, Jun-qiang Chen, Jin-lu Liu, Xin-gan Qin and Yuan Huang

    Citation: BMC Gastroenterology 2012 12:137

    Content type: Research article

    Published on:

  25. Currently there is no disease-specific outcome measure to assess the health-related quality of life (HRQOL) of pediatric patients with Eosinophilic Esophagitis (EoE). Therefore, the objective of this qualitati...

    Authors: James P Franciosi, Kevin A Hommel, Allison B Greenberg, Charles W DeBrosse, Alexandria J Greenler, J Pablo Abonia, Marc E Rothenberg and James W Varni

    Citation: BMC Gastroenterology 2012 12:135

    Content type: Research article

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  26. In this post-hoc analysis of a randomized, double blind, placebo controlled trial, we measured the sensitivity and specificity of Helicobacter pylori IgG-antibody titer changes, hematoxylin and eosin (H&E) stains...

    Authors: Harald E Vonkeman, HTJI deLeest, MAFJ van deLaar, J vanBaarlen, KSS Steen, WF Lems, JWJ Bijlsma, EJ Kuipers, HHML Houben, M Janssen and BAC Dijkmans

    Citation: BMC Gastroenterology 2012 12:133

    Content type: Research article

    Published on:

  27. Symptoms of gastro-esophageal reflux disease (GERD) in pregnancy are reported with a prevalence of 30–80%. The aim of this study was to assess the prevalence and severity of GERD symptoms during the course of ...

    Authors: Sara Fill Malfertheiner, Maximilian V Malfertheiner, Siegfried Kropf, Serban-Dan Costa and Peter Malfertheiner

    Citation: BMC Gastroenterology 2012 12:131

    Content type: Research article

    Published on:

  28. Gastroesophageal reflux disease (GERD) is associated with impaired epithelial barrier function that is regulated by cell-cell contacts. The aim of the study was to investigate the expression pattern of selecte...

    Authors: Klaus Mönkemüller, Thomas Wex, Doerthe Kuester, Lucia C Fry, Arne Kandulski, Siegfried Kropf, Albert Roessner and Peter Malfertheiner

    Citation: BMC Gastroenterology 2012 12:128

    Content type: Research article

    Published on:

  30. Gastric subepithelial tumors are usually asymptomatic and observed incidentally during endoscopic examination. Although most of these tumors are considered benign, some have a potential for malignant transform...

    Authors: Yin-Yi Chu, Jau-Min Lien, Ming-Hung Tsai, Cheng-Tang Chiu, Tse-Ching Chen, Kuo-Ching Yang and Soh-Ching Ng

    Citation: BMC Gastroenterology 2012 12:124

    Content type: Research article

    Published on:

  31. The “Rusch” intubation stylet is used to make endotracheal tube intubation easy. We designed this study to evaluate the usage of this equipment in the guidance of nasogastric tube (NGT) insertion.

    Authors: Yung-Fong Tsai, Chiao-Fen Luo, Amina Illias, Chih-Chung Lin and Huang-Ping Yu

    Citation: BMC Gastroenterology 2012 12:99

    Content type: Research article

    Published on:

  32. The ideal medication for acid-related diseases should have a rapid onset of action to promote hemostasis and cause efficient resolution of symptoms. The aim of our study was to comparatively investigate the in...

    Authors: Hiroshi Iida, Masahiko Inamori, Tetsuro Fujii, Yusuke Sekino, Hiroki Endo, Kunihiro Hosono, Takashi Nonaka, Tomoko Koide, Hirokazu Takahashi, Masato Yoneda, Ayumu Goto, Yasunobu Abe, Noritoshi Kobayashi, Hiroyuki Kirikoshi, Kensuke Kubota, Satoru Saito…

    Citation: BMC Gastroenterology 2012 12:25

    Content type: Research article

    Published on:

  33. Benign esophageal ruptures and anastomotic leaks are life-threatening conditions that are often treated surgically. Recently, placement of partially and fully covered metal or plastic stents has emerged as a m...

    Authors: Petra GA van Boeckel, Kulwinder S Dua, Bas LAM Weusten, Ruben JH Schmits, Naveen Surapaneni, Robin Timmer, Frank P Vleggaar and Peter D Siersema

    Citation: BMC Gastroenterology 2012 12:19

    Content type: Research article

    Published on:

  34. Medical management of GERD mainly uses proton pump inhibitors. Alginates also have proven efficacy. The aim of this trial was to compare short-term efficacy of an alginate (Gaviscon®, 4 × 10 mL/day) and omeprazol...

    Authors: Denis Pouchain, Marc-André Bigard, François Liard, Marc Childs, Annick Decaudin and Donna McVey

    Citation: BMC Gastroenterology 2012 12:18

    Content type: Research article

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  35. Non-invasive tools for gastric cancer screening and diagnosis are lacking. Serological testing with the detection of pepsinogen 1 (PG1), pepsinogen 2 (PG2) and gastrin 17 (G17) offers the possibility to detect...

    Authors: Jan Bornschein, Michael Selgrad, Thomas Wex, Doerthe Kuester and Peter Malfertheiner

    Citation: BMC Gastroenterology 2012 12:10

    Content type: Research article

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  36. H. pylori infection significantly attenuated the expression of HSP70 in gastric mucosal cells. However, the role of HSP70 cancellation in H. pylori-associated cell damages is largely unclear.

    Authors: Weili Liu, Yan Chen, Gaofeng Lu, Leimin Sun and Jianmin Si

    Citation: BMC Gastroenterology 2011 11:146

    Content type: Research article

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  37. The reported incidence of ulcer formation in the gastric tube in esophageal replacement is rare.

    Authors: Takahisa Suzuki, Takafumi Ando, Akihisa Usami, Masataka Shinoda, Hitomi Takashi, Mutsumi Murayama, Isako Uchiyama, Kazuhiro Morise, Shinya Endo, Nobuhiro Haruki, Kazuhiro Tashiro and Hidemi Goto

    Citation: BMC Gastroenterology 2011 11:139

    Content type: Case report

    Published on:

  38. Gastric carcinoma is the second commonest cause of cancer deaths worldwide. Early detection and diagnosis of gastric cancer in the stomach is important for improving the prognosis of gastric cancer. This retro...

    Authors: Jing Zhang, Shi-Bin Guo and Zhi-Jun Duan

    Citation: BMC Gastroenterology 2011 11:135

    Content type: Research article

    Published on:

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BMC Gastroenterology

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