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Parameters
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Derivation cohort (n = 629)
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Validation cohort (n = 314)
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P value
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|---|
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Age, years
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55 (14)
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53 (14)
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0.37
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Male sex
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484 (76.9%)
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243 (77.3%)
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0.88
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BMI
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24.16 (3.92)
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23.88 (3.78)
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0.30
|
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Systolic blood pressure (mmHg)
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115 (22)
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112 (25)
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0.31
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Cirrhosis etiology
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|
Hepatitis B virus n (%)
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629 (100%)
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314 (100%)
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1.00
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Variceal bleeding, n (%)
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369 (58.7%)
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167 (53.2%)
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0.11
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Heart rate
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78 (21)
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80 (22)
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0.81
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Hemoglobin, g/L
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97 (46)
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99 (49.25)
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0.72
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Total leukocyte count, × 109/L
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3.71 (1.8)
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3.9 (2.85)
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0.61
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Platelets, × 109/L
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66 (52)
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73 (56)
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0.27
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Alanine aminotransferase, IU/L
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27 (26)
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27 (27.25)
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0.83
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Creatinine, μmol/L
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78 (26.25)
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76 (23)
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0.06
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Sodium, mmol/L
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139.8 (5.5)
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139.6 (4.93)
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0.64
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Bilirubin, mmol/L
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24 (28.72)
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23.6 (26.6)
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0.71
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Albumin, g/L
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31.1 (8.45)
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31.5 (9.53)
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0.97
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Triglyceride
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0.73 (0.46)
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0.79 (0.51)
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0.09
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Cholesterol, mmol/L
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3.01 (1.31)
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3.1 (1.33)
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0.32
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High density lipoprotein, mmol/L
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0.83 (0.49)
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0.84 (0.49)
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0.58
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Low-density lipoprotein, mmol/L
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1.63 (0.97)
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1.64 (1.05)
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0.59
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International normalized ratio
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1.22 (0.3)
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1.23 (0.33)
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0.77
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Fibrinogen, g/L
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1.76 (0.85)
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1.78 (0.88)
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0.45
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Hepatocellular carcinoma
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137 (21.7%)
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76 (24.2%)
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0.40
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Previous bleeding, n (%)
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203 (32.2%)
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119 (35.9%)
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0.09
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Ascites, n (%)
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367 (58.3%)
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183 (58.2%)
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0.98
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Hepatic Encephalopathy, n (%)
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56 (8.9%)
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22 (7.0%)
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0.32
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β-blocker use, n (%)
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133 (21.1%)
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73 (23.2%)
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0.46
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QTc, ms
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435 (33)
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433.5 (37)
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0.57
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QTc prolongation, n (%)
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148 (23.5%)
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81 (25.7%)
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0.44
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PRBC transfusion (%)
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170 (27%)
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105 (27.8%)
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0.04
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> 2 PRBC transfusion (%)
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57 (33.5%)
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43 (41.0%)
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0.03
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Endoscopic treatment, n (%)
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260 (41.3%)
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153 (40.5%)
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0.03
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TIPS treatment, n (%)
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23 (3.6%)
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11 (2.9%)
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0.91
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6-Week death, n (%)
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66 (10.4%)
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34 (10.8%)
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0.75
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Prognostic scores
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Child–Pugh score
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8 (4)
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8 (4)
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0.86
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Child–Pugh A
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202 (32.1%)
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93 (29.6%)
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Child–Pugh B
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264 (42%)
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141 (44.9%)
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Child–Pugh C
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163 (25.9%)
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80 (25.5%)
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MELD
|
10.98 (7.76)
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10.8 (7.02)
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0.19
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ALBI
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−1.72 (0.96)
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−1.71 (0.99)
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0.89
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D’Amico model
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−1.32 (1.39)
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−1.27 (1.4)
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0.75
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Augustin model
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−2.95 (2.29)
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−2.95 (2.22)
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0.97
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Glasgow-Blatchford score
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9 (7)
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9 (8)
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0.74
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AIMS65
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1 (1)
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1 (1)
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0.88
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- PBRC packed red blood cells transfused; All values are expressed as median (IQR), or n (%)
